Detoxification

Are you afraid of being poisoned? By food for example? Sure you are. That's why you
wash your food and cook it properly. Because you know that if you don't, you may get
stomach upset, diarrhea and headaches. But that won't last long, right? What you don't
know is: you ingest poisons you don't know about and get so sick that you may die.
Symptoms can come so late and be so unspecific, that help will come too late.
August 14, 1996. The professor of chemistry at Dartmouth College, New Hampshire,
Karen Wetterhahn, who was specializing in toxic metal exposure, accidentally spills a
few drops of an innocent looking, colorless Mercury component called dimethylmercury
on her hands, covered by latex gloves. She knew that dimethylmercury is very toxic. What she didn't know was: it can and it did penetrate her undamaged latex gloves and her skin and deadly poisoned her whole body in 15 seconds. She was fine and she didn't have any symptoms for a few
months and considered herself healthy. Six months later she became very sick and in January 1997 was admitted to the hospital. Then she went into coma despite being treated and died in June 1997 (1).
What strikes me in this case is: even though everybody knew that she was dealing with
mercury, they couldn't make a diagnosis early enough to save her life. That's how
dangerous toxins are. That is how difficult it is to diagnose poisoning.
But she was not alone.

210 BC. Ancient China. The Emperor of the United China and the initiator of Great Wall
of China project Uin Shi Huang is looking for eternal life. But how can he get it? He
believes it is hidden in Penglai City on Penglai mountain, which was the base of the
Eighth Immortals. The Emperor sends thousands of men on the ships to find this
mountain. Nobody came back, because they knew: without the elixir of life they would
be killed. Therefore they went ahead and found and colonized Japan. That's why the
Chinese Emperor had to get magic pills from his doctors and scientists. After taking
them he died. The reason: the “magical” pills contained too much mercury (2).
Ultimately, the pills forced him to realize his mortality, but they made his name
immortal because he became the first famous man, poisoned and killed by one of the
most dangerous and well known contemporary poisons – mercury.
The privilege of being poisoned by mercury does not only belong to famous people.
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Have you ever heard the expression: “mad as a hatter”? You probably have. What you
may not know is: in 18th and 19th centuries many felt hat manufacturing workers went
mad because they got too much mercury exposure from solutions for curing animal
pelts. Apparently mad was Theophillius Carter, whom Lewis Carroll, the author of " Alice's Adventures in Wonderland ", personally knew and who was believed to have inspired the vivacious character: the Mad
Hatter. Don't forget that selling hats was the dominant trade at that time. Mercury is very dangerous: it damages the brain, nerves, kidneys and lungs. It causes fatigue, pains, itching, swelling, hair and teeth loss, muscle weakness, memory problems, irritability, personality changes and insomnia. It blocks your body from clearing
catecholamines, you get too much epinephrine with resulting palpitations, sweating and high blood pressure. Enough? But how can you get this deadly toxin in your body?
October 23, 2008. Broadway Manhattan New York. Famous American actor Jeremy
Piven appears in the Broadway hit play "Speed-the-Plow", costarring with Elisabeth
Moss from Mad Men and Raul Esparza, three times Tony nominee. But very soon Mr.
Piven misses a few performances and then announces, that he's not going to perform
because of a sudden and mysterious illness (3). The author on the play David Mamet
was joking that Mr. Piven decided to leave "to pursue a career as a thermometer". It was
a very cruel joke, because Mr. Piven was suffering from Mercury toxicity. But how could
he get that? Sushi twice a day for 20 years and possibly Chinese herbs. But sushi is not
the only source you can get mercury from. Other sources of mercury are thymerosal
from vaccines, fluorescent lamps, cosmetics, waste disposal and other human generated
sources, as well as dental amalgams. According to OSHA dental amalgam is toxic and
dentists cannot throw it into the waste basket. However, they have been allowed to put it
into your mouth for 15 to 20 years. Funny? Not really.
Mercury is not the only heavy metal that is deadly poison. There is another one, that is
always around us. It poisoned and even killed a lot of human beings, celebrities
included. But it sometimes takes more than one century to determine what the killer is.
May 7, 1824 Kärntnertor theater in Vienna. Famous composer and conductor Ludwig
van Beethoven is eager to defeat italian composers like Rossini in Vienna, where italian
music was dominating. He changes the premiere of his Symphony #9 from Berlin to
Vienna. He knew, that this is the first time a composer would be using voices in a
symphony. What he did not know was: Symphony # 9 will become the best known
piece of classical music ever known and the part if it, called "Ode of Joy" will become the
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European Anthem. He is standing in front of the orchestra and chorus and conducting.
The symphony is finished. Music ends. Audience bursts into cheers. It gives the
composer standing ovations. But strangely Ludwig van Beethoven is still conducting.
Orchestra players knew the composer's best kept secret and immediately realized what
is going on. The contralto Caroline Unger comes to the conductor and turns Beethoven
around to see audience's standing ovations. People in the audience knew, that they just
heard one of the best music pieces ever written. What they did not know was: the
composer and conductor Ludwig van Beethoven was deaf. But it was not only deafness,
that made him seek physician after physician for help. He was suffering from
abdominal pain, indigestion, mood swings and depression. His health was deteriorating rapidly. Soon he
became bedridden and died in 1827 at age 57. Just before his death he wrote: "As soon as I am
dead, if Dr. Schmidt is still alive, ask him in my name to discover my disease..." (4). Even his autopsy did not shed any light on the cause of his death. Despite his request for autopsy the cause of his deafness and death remained a mystery. Until now. One extravagant stealing and one heroic act of mercy helped to solve the mystery of Beethoven's deafness and death and to write a new page in the toxicology story. 1994. London. Famous Sotheby's auction. Mr. Ira Brilliant, the founder of the Beethoven Center at San Jose State University in 1985, is sitting quietly watching the new items appearing in the auction.

What he is looking for is not the art masterpiece, for which Sotheby's is famous. He is
looking for a lock of 582 brown, white and gray hair in wood and glass frame. As per
Sotheby's catalog this lock of hair is Ludwig van Beethoven hair. That is why Mr. Ira
Brilliant buys it for 7200 dollars thanks to money given by a urologist Dr. Alfredo
Guevara from Nogales Arizona. But they want to be sure, that the lock of hair really
belongs to Ludwig van Beethoven. They request proof. And a few months later they
received a letter from Denmark signed by Mr. Thomas Wassard Larsen. His grandfather
Dr. Kay Alexander Fremming was practicing in a small village Gilleleje in Denmark,
which was only 10 miles from Norway by water. He was rescuing Jews from Nazis, and
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one of the salvaged grateful Jews gave him his most precious thing -- the lock of
Beethoven's hair as a gift. But how did this Jew obtain it?

Stealing is not a good idea. Especially from the dead. But when Ferdinand Hiller,
Jewish composer and Beethoven's admirer snipped the lock of Beethoven’s hair on the
next day of his death, he did not think about it. He just wanted the reminder. And other
people did the same things too. What Ferdinand Hiller did not know was: this lock of
hair would eventually shed a light on the cause of Beethoven's death.
Now Mr. Ira Brilliant and Dr. Alfredo Guevara were sure that the lock of hair really was
Beethoven's. And a bold idea came to them: what if, by analyzing his hair, they could
figure out the cause of Beethoven's death? The hair went to forensic experts at the
University of Arizona Medical Center in Tucson. What they found shocked them.
Beethoven's hair was heavily loaded with another deadly heavy metal -- Lead!
Lead damages almost every part of our body: the brain and the rest of out nervous
system, heart, digestive system, kidneys, bones etc. It causes learning problems,
insomnia, mood disorders, abdominal pain, tremors, seizures and death. Children are
especially sensitive to lead and may develop permanent damage. But where does lead
poisoning come from? Paints! Other sources are air, food, soil, and consumer products.
One hypothesis about why Roman empire fell is that they drank water from pipes made from lead!
What about if lead and mercury are together? They multiply the damage, made by both of them. When they are together it is not like 9 plus 9 equals 18. It is like 9 multiplied by 9 equals 81!

When did you last check your mercury and lead levels?

Even though heavy metal toxicity is extremely dangerous and difficult to recognize, that was not what really scared the scientists. 1980s. Fishermen in the US and Canada are very concerned because of declining salmon
population. So scientists had to look into it. It looked like there were too many females
and witty little males. But how did that happen? Mother Nature started making major
mistakes? So they decided to check male to female ratio after hatching. And it was okay.
But when they checked the ratio down the river females outnumbered males. So what
happened to males? Did they die? There was no evidence of it. So how do they
disappear? This remained a mystery.

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Until they decided to check salmon's genes. Initially scientists refused to believe what
they found. Salmon with male genes were actually female. So somehow after hatching
males became females while going down the river. That's what scientists had never
heard or seen before -- sex reversal. First they tried to explain this by low temperature–
which didn't work. Then they tried to explain sex reversal by partial migration between
sex chromosomes because of mysterious external forces– this also failed. Eventually
every well-known fact came to their mind as a plausible explanation: a male can become
a female issue in early life it is exposed to estrogens. But there are no natural estrogens
in the Columbia River, where the studies were done. So it must be other man-made
compounds like pesticides, detergents etc., that work like natural hormones–so-called
environmental estrogens (5). That's when they really became scared. Because it was not
the only disaster they found.

1970. Lake Ontario. Biologist Mike Gilbertson observes and unusually high death rate
among gull chicks. What he found was: 80% of the dead chicks died before hatching.
But what striked him as bizarre was that they had unusual deformities. He desperately
searched for an explanation. The deformed chicks looked oddly familiar, they looked
like he has used them before. But he could not remember where. Suddenly his memory
gives him an answer: he had seen equally strange looking chicks in the past that were
exposed to a dioxide poisoning. But his colleagues almost laughed at him: there was no
dioxide in Lake Ontario. It took them more than 20 years to solve this mystery.
1988. Great Lakes. Mrs. Theo Colborn, who is a professor of zoology at the University of
Florida, Gainesville, is interested in unusual gull's behavior: two gulls nesting together.
Usually they are male and a female, who nest together. What she observed was: they
were both females, nesting together. Were they “gay gulls”? Colborn began grasping for
an answer. The only thing that can change a gull's behavior is hormones. But she is
trained in zoology and does not know that much about hormones. It looked like
endocrinologists, who could and who should solve the mystery, were not really interested in it. So she didn't have any choice, but to buy aendocrinology textbook and look into it herself.
She learned that Swedish toxicologist Bengtsson
was concerned with fish testicle shrinkage
because of Baltic water contamination by
organochlorine compounds. Could it be hormone
disruption? In 1991 she gathered 21 scientists
from 15 different areas to discuss the facts about
gender change secondary to environmental
toxins, that behave like hormones. And they
issued a document named "Wingspread
Consensus Statement" (6) in 1991. This meeting
became famous because that is where the terms
“endocrine disruption” and "endocrine
disruptors" were made.
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But why are they so dangerous?
Normally hormones are substances that are messengers, like errand boys, that deliver
the signals from our brain derivatives to endocrine glands and then to the rest of our
body. Therefore only a tiny amount of hormone is necessary to transmit the signal. It's
like a small key can open a huge safe. That's why only a few molecules of an
environmental toxin work like hormones – endocrine disruptor, is necessary to destroy
the beautiful regulation system mother nature created for us. That is why they are so
dangerous, probably much more dangerous than mercury, lead, cadmium etc.
Remember Lake Ontario- dead chicks and no dioxin? That's because the amount of
poison can be so small, that it cannot be picked up by regular water analysis. And the
consequences of being exposed to endocrine disruptors are disastrous: the body cannot
regulate itself anymore, even to the extent that gender is changed. It's like if you try to
insert the wrong key in a your apartment door lock and it gets stuck and you break the
key: you cannot even to open your apartment with the right key and you are stuck.
Endocrine disruptors are everywhere: in our water, food, air, dust, detergents,
cosmetics, pesticides, plastics, etc.. They can cause fertility problems, fetal loss, cancer,
menstrual problems, low IQ and learning problems, behavioral problems, ADHD,
autism etc.
But shouldn't mother nature protect us from various toxins?
Normally when toxins get into our body, they are removed by the liver in two stages.
First stage which is called “phase 1” is immediate inactivation of the toxin by the group
of enzymes called cytochrome P 450, when intermediate byproducts from the toxin are
made. The next stage called “phase 2” makes these intermediate byproducts watersoluble
so that they are going to be excreted in the bile through the gut or by the
kidneys. As soon as this is accomplished, the toxin is inactivated and byproducts are
removed from the body. Danger is over.
But what if our body is not familiar or not prepared for the toxin it gets from outside?
Like heavy metals. Or like a man-made endocrine disruptors: pesticides, plastics,
cosmetics etc.? Or your liver is getting too much toxins so that it doesn't have enough
resources to deal with them? Then the natural detoxification system is broken. And
you're in real trouble.
Bottom line is simple: if you are experiencing symptoms of toxicity such as
• fatigue
• mood problems or psychiatric problems
• ADHD
• insomnia
• palpitations
• tingling and/or abnormal sensations
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• unexplained high blood pressure
• menstrual problems
• memory problems, etc.
you may be suffering from toxins.
What you need to get better–you need to be checked by a doctor, who specializes in
detoxification.
Disclaimer:
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other government agencies. This article is not intended to medically advise individuals and should only be
used for informational purposes. In addition, this article is not intended to make any health statements.
Please consult your primary physician before making any medical decisions.
References
(1) The Karen Wetterhahn story - University of Bristol web page documenting her death, retrieved December 9, 2006.
http://en.wikipedia.org/wiki/Karen_Wetterhahn
(2)Wright, David Curtis (2001). The History of China. Greenwood Publishing Group. p. 49. ISBN 031330940X
(3) http://en.wikipedia.org/wiki/Jeremy_Piven
(4) http://www.aps.anl.gov/News/APS_News/2000/20001017.htm
(5) http://ehp.niehs.nih.gov/members/2001/109p67-69nagler/nagler.pdf
(6) www.endocrinedisruption.com